衰老过程中的脂肪组织炎症研究进展

Adipose Tissue Inflammation in Aging

传统上,脂肪组织在肥胖和饮食相关代谢紊乱研究中被视为一种内分泌器官,然而,随着研究揭示白色脂肪组织作为能量储存、脂质代谢位点和脂肪因子分泌者发挥作用,脂肪组织已被认为是年轻肥胖和老年肥胖代谢健康的重要器官。在衰老研究的领域内,抗衰老药senolytics已经成为该领域的研究热点,清除衰老细胞能减少与年龄相关的疾病。更有意思的是,抗衰老研究显示,这些衰老细胞,特别是p16(Ink4a)阳性衰老细胞可在脂肪组织、骨骼肌和眼睛中积累。暗示脂肪组织在衰老中的重要性,并拓宽了衰老细胞跨越免疫和非免疫细胞途径影响机体寿命和健康的研究范围。

Adipose tissue has traditionally been viewed as an endocrine organ in studies of obesity and diet-associated metabolic disorders.However,as studies reveal the role of white adipose tissue as energy storage,lipid metabolism site,and adipokine secretor,it has become recognized as an important organ for metabolic health in both young obese people and old obese people.Senolytics has taken the spotlight in the aging research,where the clearance of senescent cells has shown the effect of attenuating age-related disorders.More interestingly,anti-aging studies have also revealed that these senescent cells,specifically p16(Ink4 a) positive senescent cells,accumulate within adipose tissue,skeletal muscles,and eyes.These results implicate the importance of adipose tissue in aging and broaden the scope of research on the effects of senescent cells on life span and health across immune and non-immune cell pathways.