益生菌辅助治疗对幽门螺杆菌相关性慢性胃炎患者的疗效、炎症因子及VEGF水平的影响

Effect of probiotic adjuvant therapy on the efficacy, inflammatory factors and levels of VEGF in patients with Helicobacter pylori-associated chronic gastritis

目的 探讨益生菌辅助治疗对幽门螺杆菌相关性慢性胃炎患者的疗效、炎症因子及血管内皮生长因子(vascular endothelial growth factor,VEGF)水平的影响。方法 选取广东省人民医院2015年7月 2017年7月接诊的80例幽门螺杆菌相关性慢 性胃炎患者进行研究,根据治疗方法的不同,将患者均分为对照组和观察组。对照组采取三联疗法(奥美拉唑+克拉霉素+阿莫西 林)治疗,观察组在对照组的基础上采取益生菌辅助治疗。比较分析2组患者治疗后的临床疗效,治疗前后的炎症因子水平、VEGF 水平以及治疗后的不良反应发生情况。结果 观察组总有效率、幽门螺杆菌清除率均明显高于对照组(P<0.05)。治疗后,观察 组白细胞介素6(interleukin-6,IL-6)、白细胞介素8(interleukin-8,IL-8)和C反应蛋白(C-reactive protein,CRP)水平均明 显低于对照组(P<0.05)。治疗后,观察组VEGF水平明显低于对照组(P<0.05)。治疗后,观察组不良反应发生率明显低于对 照组,2组差异有统计学意义(P<0.05)。结论 益生菌辅助治疗对幽门螺杆菌相关性慢性胃炎患者的疗效显著,能够改善 炎症因子和VEGF水平,减少不良反应的发生,值得临床上应用及推广。

Objective To explore the effect of probiotics adjuvant therapy on the efficacy, inflammatory factors and levels of VEGF in patients with chronic gastritis associated with Helicobacter pylori. Methods Eighty cases of Helicobacter pylori-associated chronic gastritis treated in our hospital between July 2015 and July 2017 were studied. According to treatment methods, the patients were equally divided into the control group and observation group. The control group was treated with triple therapy(omeprazole+Clarithromycin+amoxicillin), while the observation group was additionally treated with probiotics. The clinical effects, levels of inflammatory factors, vascular endothelial growth factor (VEGF)and adverse reactions were compared between the two groups. Results The total effective rate and clearance rate of Helicobacter pylori in the observation group were significantly higher than those in the control group, and the difference was statistically significant(P<0.05).After treatment, the levels of interleukin-6(IL-6), interleukin-8(IL-8) and C-reactive protein(CRP)in the observation group were significantly lower than those in the control group(P<0.05). The level of VEGF in the observation group was significantly lower than that in the control group(P<0.05).The incidence of adverse reactions in the observation group was significantly lower than that in the control group, and the difference between the two groups was statistically significant(P<0.05). Conclusion Probiotics adjuvant therapy for chronic gastritis associated with Helicobacter pylori has a significant effect, which can improve the levels of inflammatory factors and vascular endothelial growth factor, reduce the incidence of adverse reactions, so it worthy of clinical application.