氨溴索联合布地奈德雾化吸入治疗小儿毛细支气管炎的临床效果

Clinical effect of Ambroxol combined with Budesonide aerosol inhalation in treatment of children with bronchiolitis

目的探讨氨溴索联合布地奈德雾化吸入治疗小儿毛细支气管炎(BO)的临床效果。方法选取2016年7月~2017年9月我院收治的97例BO患儿作为研究对象,按照治疗方法的不同将其分成实验组(n=49)和参照组(n=48)。参照组行常规对症治疗,实验组在此基础上给予氨溴索+布地奈德联合雾化吸入治疗,观察两组治疗后血气指标、临床症状、临床效果、不良反应总发生率。结果两组治疗前血气指标水平比较,差异无统计学意义(P>0.05),两组治疗后血氧饱和度(SpO2)、动脉血二氧化碳分压(PaCO2)、血氧分压(PaO2)水平与治疗前比较,均有显著变化,差异有统计学意义(P<0.05);两组治疗前血气指标水平比较,差异无统计学意义(P>0.05),实验组治疗后SpO2、PaO2水平明显高于参照组,实验组PaCO2水平明显低于参照组,差异有统计学意义(P<0.05);实验组哮鸣音、气促、湿啰音、呼吸困难、咳嗽等各项症状消失时间明显短于参照组,差异有统计学意义(P<0.05);实验组总有效率为95.92%,明显高于参照组的81.25%,差异有统计学意义(P<0.05);实验组不良反应总发生率为8.16%,略高于参照组的6.25%,但差异无统计学意义(P>0.05)。结论对BO患儿应用氨溴索+布地奈德雾化吸入效果显著,可快速改善临床症状,且未增加不良反应,安全有效,值得推广应用。

objective To probe into the clinical effect of Ambroxol combined with Budesonide aerosol inhalation in treatment of children with bronchiolitis(BO).Methods A total of 97 cases of children with BO who were treated in our hospital from July 2016 to September 2017 were selected as the research object,and were divided into the experimental group(n=49)and the control group(n=48)by different treatments method.The control group received routine symptomatic treatment,while the experimental group was treated with Ambroxol and Budesonide combined with aerosol inhalation.Then,the blood gas index,clinical symptoms,clinical effect and total incidence of adverse reactions after the treatment of two groups were observed.Results There was no significant difference in blood gas index between the two groups before treatment(P>0.05).After treatment,the levels of the blood oxygen saturation(SpO2),the partial pressure of carbon dioxide(PaCO2)and blood sample partial pressure(PaO2)of two groups were compared with before the treatment,which was significantly changed,and the differences were statistically significant(P<0.05).After treatment,SpO2 and PaO2 levels in the experimental group were significantly higher than those in the control group,while PaCO2 in arterial blood in the experimental group was significantly lower than that in the control group,and the differences were statistically significant(P<0.05).The disappearance time of wheezing,shortness of breath,moist rale,dyspnea and cough in the experimental group were significantly shorter than those in the control group,and the differences were statistically significant(P<0.05).The total effective rate in the experimental group was 95.92%,which was significantly higher than that in the control group of 81.25%,and the difference was statistically significant(P<0.05).The total incidence of adverse reaction of the experimental group was 8.16%,which was slightly higher than that in the control group of 6.25%,but there was no significant difference between the two groups(P>0.05).Conclusion For children with BO,the application effects of Ambroxol and Budesonide aerosol inhalation are significant,which can quickly improve clinical symptoms,and does not increase too many adverse reactions,and it is safe and effective,thus it is worth applying.