TRIMs家族蛋白在肝细胞癌中的研究进展

Research progress of TRIMs family proteins on hepatocellular carcinoma

TRIMs家族蛋白是一种具有泛素化连接酶E3活性的功能蛋白,它们在调控细胞周期、凋亡、分化、病毒免疫应答以及肿瘤发生等过程中发挥着重要作用。最近研究表明,部分TRIMs家族蛋白成员参与了肝细胞癌(HCC)的发生与发展。此外,越来越多的证据表明TRIMs家族蛋白在HCC发生中不仅具有促癌作用,同时还有抑癌效应。因此,理解TRIMs家族蛋白在HCC发生与发展中的双重调控机制对HCC的诊断、治疗及预后评估都有着重要的临床意义。现将TRIMs家族蛋白在HCC中的研究进展作一综述。

TRIMs family proteins are functional proteins with ubiquitinated ligase E3 activity.They play an important role in regulating cell cycle,apoptosis,differentiation,viral immune response and tumorigenesis.Recent studies have shown that some members of TRIMs family are involved in the occurrence and development of hepatocellular carcinoma(HCC).In addition,more and more evidences show that TRIMs family proteins not only promote the development of HCC,but also inhibit the growth of HCC.Therefore,understanding the dual regulation mechanism of TRIMs family proteins in the occurrence and development of HCC has important clinical significance in the diagnosis,treatment and prognostic evaluation of HCC.This paper reviews the research progress of TRIMs family proteins in HCC.