灵杆菌合成灵菌红素的转录调控

Research progress in transcriptional regulation of prodigiosin biosynthesis in Serratia marcescens

灵菌红素是一种具有多种生物活性的红色素,具有巨大的经济价值和广阔的应用前景。灵杆菌是灵菌红素的生产菌株,同时也是研究灵菌红素合成的模式菌株。本文综述了转录水平上调控灵杆菌合成灵菌红素的研究进展,总结了双(多)组分调控系统、群体感应系统、σ因子和转录因子在调控灵杆菌合成灵菌红素过程中发挥的作用,并对未来的研究方向进行了展望。

Prodigiosin is a red pigment with multiple biological activities,and of great economic value with promising application.Serratia marcescens is a major producer of prodigiosin,and the model organism for prodigiosin biosynthesis research.This paper reviews recent progresses in transcriptional regulation of prodigiosin synthesis in S.marcescens,illustrating the function of two/multiple component system,quorum sensing system,σfactor and transcriptional regulator in modulating prodigiosin biosynthesis.Moreover,further research focuses are discussed.