高血压人群中血糖与血压的因果关系研究

Study on the causal relationship between blood glucose and blood pressure in hypertension

目的本研究使用空腹血糖(fasting plasma glucose,FPG),收缩压(systolic blood pressure,SBP)和舒张压(diastolic blood pressure,DBP)描述高血压人群中血压(blood pressure,BP)和血糖的因果关系。方法研究共选取有两次FPG,SBP和DBP测量值的4195名研究对象。采用双向因果关联模型描述BP和FPG的因果关系,并用逐性回归验证。结果共4195例高血压患者,平均年龄(53.67±10.20)岁,平均随访时间为(28.86±3.34)月。双向因果关系模型中,基线SBP影响随访FPG的路径(ρ1=0.034,P=0.009)和基线FPG影响随访SBP的路径(ρ2=0.032,P=0.018)均差异有统计学意义,同时在线性回归中,也存在SBP和FPG相互影响,互为因果的关系(均P<0.05)。结论在高血压患者中血压和血糖之间存在双向关系,即SBP与FPG不分先后,互为因果。

Objective To describe the causal relationship between blood pressure and blood glucose in hypertension by using fasting plasma glucose(FPG),systolic blood pressure(SBP)and diastolic blood pressure(DBP).Methods A total of 4195 hypertension cases with two times measurements of FPG,SBP and DBP were selected for the study.The causal relationship between BP and FPG was described by the cross-lagged panel analysis,and tested by stepwise linear regression model.Results The mean age of 4195 cases was 53.67±10.20 years and the mean follow-up time was 28.86±3.34 months.The path of baseline SBP to follow-up FPG(ρ1=0.034,P=0.009)and the path of baseline FPG to follow-up SBP(ρ2=0.032,P=0.018)were both significant in cross-lagged panel analysis.SBP and FPG interacted as both cause and effect in stepwise linear regression model(P<0.05).Conclusions The causal relationship between BP and FPG is found to be reciprocal in hypertensive individuals.Therefore,SBP and FPG interact as both cause and effect.