肿瘤靶向治疗和免疫治疗——眼科系统毒性反应的诊治

Clinical Diagnosis and Treatment Recommendations for Ocular Toxicities of Target Therapy and Immune Checkpoint Inhibitor Therapy

靶向治疗和免疫治疗给晚期肿瘤患者带来了希望。但是治疗过程中的药物毒副作用也随着药物的普及而逐渐展现出来。其中眼部的毒副反应常被患者和医生忽视。眼部的不良反应包括从眼睑、睫毛、结膜、角膜、葡萄膜、视网膜、视神经和眼眶等,可累及眼部的所有组织。本文就靶向治疗和免疫治疗相关的眼部毒副作用的诊断和治疗给予相应的描述和建议。

The increasing use of target therapy and immunocheckpoint inhibitors in cancers has brought new hope of survival to patients with advanced tumors.However,more and more adverse side-effects and toxicities of these medications had been reported,affect almost all human organs including the eye.These adverse effects may affect the entire ocular tissues,like eyelid,eye lashes,conjunctiva,cornea,uvea,retina,optic nerve and so on,which are always been ignored by patients and doctors.In this paper we will summarize the characteristics of the related ocular diseases and give our advice on how to diagnose and manage these diseases.