摘要
近年来,免疫检查点抑制剂(immune checkpoint inhibitors,ICIs)已成为肿瘤治疗的突破性进展之一。但随着ICIs的广泛应用,这类药物所导致的免疫相关副反应(immune-related adverse events,irAEs)也逐渐引起人们的重视。研究发现,irAEs几乎可影响到人体的各个器官。本文主要针对ICIs在风湿方面毒副反应的临床特点展开综述,并且总结了具有基础风湿病的患者在使用ICIs后的免疫相关副反应,最后对这类副反应的治疗进行了探讨。
Immune checkpoint inhibitors(ICIs)have made remarkable breakthroughs in cancer treatment.However,the widely use of ICIs is associated with a spectrum of immune-related adverse events(irAEs).These adverse events can affect any organ system.In this article,we have made a systemic review about the clinical characteristics of rheumatic irAEs,and also summarized irAEs in patients with pre-exsiting rheumatic disease.We also focus on the management of rheumatic irAEs.
作者
周佳鑫
王迁
段炼
斯晓燕
张丽
刘小伟
李玥
王汉萍
郭潇潇
张文
张力
Jiaxin ZHOU;Qian WANG;Lian DUAN;Xiaoyan SI;Li ZHANG;Xiaowei LIU;Yue LI;Hanping WANG;Xiaoxiao GUO;Wen ZHANG;Li ZHANG(Department of Rheumatology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences,Beijing 100730,China;Department of Endocrinology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences,Beijing 100730,China;Department of Respiratory medicine,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences,Beijing 100730,China;Department of Clinical Laboratory,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences,Beijing 100730,China;Department of Ophthalmology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences,Beijing 100730,China;Department of Gastroenterology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences,Beijing 100730,China;Department of Cardiology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences,Beijing 100730,China)
出处
《中国肺癌杂志》
CAS
CSCD
北大核心
2019年第10期671-675,共5页
Chinese Journal of Lung Cancer
基金
中国医学科学院医学与健康科技创新工程资助项目（No.2016-I2M-1-002）资助~~
关键词
免疫检查点抑制剂
免疫相关副反应
风湿性疾病
治疗
Immune checkpoint inhibitors
Immune-related adverse events
Rheumatic disease
Treatment
