维生素D与多囊卵巢综合征的研究进展

Research progress on vitamin D andpolycystic ovary syndrome

多囊卵巢综合征(PCOS)是常见的妇科内分泌疾病,临床表现为月经稀发或闭经、不孕、多毛、肥胖、糖脂代谢障碍等。PCOS是多病因发病,从青春期迁延至绝经期,呈现高度异质性,并涉及多个系统的复杂性疾病。研究发现维生素D不仅可调控钙、磷代谢和维持骨代谢稳定,还参与宿主防御、炎症、免疫调节、组织修复等一系列病理生理过程。流行病学、临床及动物研究均证实,维生素D与PCOS发病有一定的关系,包括参与PCOS卵泡发育的调控及内分泌代谢等多个途径。

Polycystic ovary syndrome(PCOS) is a common gynecological endocrine disease,with clinical manifestations of rare menstruation or amenorrhea,infertility,hairy,obesity,disorders of glucose and lipid metabolism.PCOS is a multi-etiological disease which extends from puberty to menopause,presenting a high degree of heterogeneity and involving complex diseases of multiple systems.Studies have found that vitamin D not only regulates the metabolism of calcium and phosphorus and maintains the stability of bone metabolism,but also participates in a series of pathophysiological processes such as host defense,inflammation,immune regulation and tissue repair.Epidemiological,clinical and animal studies have confirmed that vitamin D has a certain relationship with the incidence of PCOS,including the regulation of PCOS follicular development,endocrine metabolism and other pathways.