系统性红斑狼疮继发抗磷脂抗体综合征合并Fahr综合征一例报道并文献复习

Antiphospholipid Antibody Syndrome with Fahr’s Syndrome Secondary to Systemic Lupus Erythematosus:a Case Report and Literature Review

在系统性红斑狼疮中,约20%的患者可继发抗磷脂抗体综合征,但同时合并Fahr综合征的患者临床上甚是罕见。本文报道1例系统性红斑狼疮继发抗磷脂抗体综合征且合并Fahr综合征的患者,并对相关文献进行回顾,探讨颅内广泛脑组织钙化的发病机制及治疗方法,从而发现抗磷脂抗体在系统性红斑狼疮并发Fahr综合征方面所发挥的作用,提示临床医生早期诊断继发性抗磷脂抗体综合征并给予个体化抗凝治疗非常必要。

In systemic lupus erythematosus(SLE) patients,about 20% have secondary antiphospholipid antibody syndrome(AAS),but it is rare for them with secondary Fahr’s syndrome at the same time.We reported a case of AAS with Fahr’s syndrome secondary to SLE,and reviewed the related literature.Moreover,we discussed the pathogenesis and treatment of extensive intracranial calcifications,and the role of antiphospholipid antibody in the development of Fahr’s syndrome secondary to SLE.It is suggested that it is necessary for clinicians to diagnose AAS secondary to SLE at an early stage,and to give personalized anticoagulant therapy timely.