摘要
A concise total synthesis of(R,R)-secoisolariciresinol was achieved in four steps, featuring a biomimetic β-β’ radical coupling of two dihydroferulic acid derivatives. The conversion of secoisolariciresinol to other related lignans was ongoing.
本文报道了木质素(R,R)-Secoisolariciresinol的一种高效合成方法,该方法以二氢阿魏酸衍生物的仿生β-β’-自由基二聚为关键反应,仅以4步完成了天然产物的合成。将Secoisolariciresinol向其他相关木脂素的转化研究正在进行中。
基金
The Drug Innovation Major Project(Grant No.2018ZX09711-001-005-005)