绝经后女性乳腺浸润性癌患者的钼靶X线特征与KKii--67表达的关系研究

Relationship between molybdenum target X-ray characteristics and the expression of Ki-67 in postmenopausal women with invasive breast cancer

目的探讨绝经后女性乳腺浸润性癌的钼靶X线特征与乳腺浸润性癌组织中Ki-67表达的关系。方法选取绝经后女性乳腺浸润性癌患者187例,收集所有患者的术前双侧乳腺钼靶X线影像资料,对钼靶X线的肿块形态、边缘、密度以及钙化的形态和分布等特征进行分析。术后行免疫组织化学染色法检测乳腺浸润性癌组织中Ki-67的表达情况,并对其与乳腺浸润性癌患者的钼靶X线特征的关系进行分析。结果根据钼靶X线肿块形态,形态高度恶性组患者乳腺癌组织中Ki-67的阳性表达率高于形态低度恶性组(P﹤0.05);其中,肿块形态为圆形的患者乳腺癌组织中Ki-67的阳性表达率低于肿块形态为非圆形的患者(P﹤0.05)。根据钼靶X线肿块边缘,边缘高度恶性组患者乳腺癌组织中Ki-67的阳性表达率明显高于边缘低度恶性组患者(P﹤0.01);其中,肿块边缘不清晰、毛刺征/浸润性乳腺浸润性癌患者乳腺癌组织中Ki-67的阳性表达率高于肿块边缘清晰、非毛刺征/浸润性乳腺浸润性癌患者(P﹤0.05)。根据钼靶X线钙化形态,恶性钙化组患者乳腺癌组织中Ki-67的阳性表达率明显高于非恶性钙化组(P﹤0.01)。结论乳腺癌患者的钼靶X线特征能在一定程度上反映Ki-67的表达水平,可能为乳腺癌患者的预后评估并指导综合治疗提供参考。

Objective To investigate the relationship between molybdenum target X-ray characteristics and the expression of Ki-67 in postmenopausal women with invasive breast cancer. Method 187 postmenopausal women with invasive breast cancer were selected. The molybdenum target X-ray data of all patients before operation were collected. The shape, edge, density, and morphologic aspects and distribution of calcification in the mass were analyzed. The expression of Ki-67 in invasive breast cancer tissue was detected by immunohistochemistry after operation. The relationship between Ki-67 and molybdenum target X-ray characteristics of patients with invasive breast cancer was analyzed. Result According to the lump form of molybdenum target X-ray, the positive expression rate of Ki-67 in breast cancer tissues of patients with high morphological malignancy was higher than that of patients with low morphological malignancy(P<0.05). Among them, the positive expression rate of Ki-67 in breast cancer tissues of patients with circular breast mass infiltrating was lower than that of patients with non-circular breast mass(P<0.05). According to the lump margin of molybdenum target X-ray, the positive expression rate of Ki-67 in breast cancer tissues of patients with high marginal malignancy was significantly higher than that of patients with low marginal malignancy(P<0.01). Among them, the positive expression rate of Ki-67 in breast cancer tissues of patients with non-clear edge and burr sign/invasive breast cancer was higher than that of patients with clear edge and non-burr sign/invasive breast cancer(P<0.05). According to the calcification pattern of molybdenum target X-ray, the positive expression rate of Ki-67 in breast cancer tissues in the malignant calcification group was significantly higher than that in the non-malignant calcification group(P<0.01). Conclusion Molybdenum target X-ray characteristics of breast cancer patients can reflect the expression level of Ki-67 to a certain extent,which may provide reference for prognosis evaluation and comprehensive treatment guidance of breast cancer patients.