地西他滨治疗骨髓增生异常综合征的疗效及对心肺功能的影响

Therapeutic effect of decitabine in patients with myelodysplastic syndrome and its effect on cardiopulmonary function

目的观察地西他滨治疗骨髓增生异常综合征(MDS)的疗效及对心肺功能的影响。方法根据随机数字表法将80例MDS患者分为对照组和观察组,每组40例。对照组患者给予常规高三尖杉酯碱+阿糖胞苷(HA)方案治疗,观察组患者给予地西他滨治疗。比较两组患者的治疗效果、治疗前后心肺功能相关指标及不良反应发生情况。结果观察组患者的完全缓解率明显高于对照组(P﹤0.01);治疗前,两组患者的每搏输出量(SV)、左心室射血分数(LVEF)、第1秒用力呼气容积(FEV1)和最大呼气中期流量(MMEF)比较,差异均无统计学意义(P﹥0.05);治疗后,观察组患者的SV、LVEF、FEV1、MMEF均明显高于对照组(P﹤0.01);观察组患者的不良反应总发生率低于对照组(P﹤0.05)。结论地西他滨治疗MDS的疗效较好,且对心肺功能的影响小。

Objective To observe the efficacy of decitabine in the treatment of myelodysplastic syndrome(MDS)and its effect on cardiopulmonary function.Method Eighty patients with MDS were included and randomized as control group and study group according to a random number table,with 40 cases in each group.Patients in control group were treated with conventional homoharringtonine and cytarabine regimen(HA),and patients in the study group were treated with decitabine.The therapeutic effects as well as the cardiopulmonary indicators before and after surgery,and the incidence of adverse reactions in the two groups were observed.Result The complete response rate of study group was significantly higher than that of control group(P<0.01);there were no significant differences regarding the levels of stroke volume(SV),left ventricle ejection fraction(LVEF),forced expiratory volume in one second(FEV1)and maximal midexpiratory flow(MMEF)between the two groups before treatment(P>0.05);while the SV,LVEF,FEV1,and MMEF levels in study group were statistically higher than those in the control group after treatment(P<0.01);significantly lower overall incidence of adverse reactions was observed in study group compared to control group(P<0.05).Conclusion Decitabine is therapeutically effective in the treatment of MDS,and imposes little negative effect on cardiopulmonary function.