NF-κB信号通路在大骨节病等骨关节病中的研究进展

Research progress of NF-κB signal pathway on pathogenesis of Kashin-Beck disease

大骨节病是一种致残率较高的地方性骨关节疾病,发病机制尚不明确,给病区患者造成严重的疾病负担。大骨节病患者四肢管状骨的关节软骨和骺板软骨深层软骨细胞常发生过度凋亡和坏死,NF-κB信号通路能够调控基因转录,参与细胞增殖分化凋亡等过程,因此NF-κB信号通路是否在大骨节病的发生发展中发挥重要作用,值得进一步探索。本文将对NF-κB信号通路在大骨节病研究中的进展进行综述,为进一步探索大骨节病的发病机制提供科学依据。

Kashin-Beck disease(KBD)is an endemic disease that damages the bone and joint and causes a high disability rate,however its etiology and pathogenesis are still unclear.Multiple degenerative and necrotic lesions within the articular cartilage and growth plate cartilage usually occur in KBD patients,and NF-κB signal pathway can regulate gene transcription and participate in the process of cell proliferation,differentiation,and apoptosis.Whether NF-κB signal pathway plays an important role in the occurrence and development of KBD is worth further discussion.In this paper,we summarized the research status and development progress of NF-κB signal pathway in KBD to provide scientific basis for further exploration of the pathogenesis.