病毒性肝炎与原发免疫性血小板减少症的相关性研究

Correlation between Viral Hepatitis and Primary Immune Thrombocytopenia

目的探讨病毒性肝炎(乙型、丙型)感染与原发免疫性血小板减少症(ITP)患者的相关性.方法将住院治疗的98例ITP患者分为两组,33例肝炎病毒感染(乙肝、丙肝)患者为病毒感染组,65例无肝炎病毒的患者为阴性对照组.应用酶联免疫吸附实验(ELISA)方法行乙型肝炎病毒(HBV)、丙型肝炎病毒(HCV)血清标志物检测,分析比较病毒感染组、阴性对照组的一般资料、临床表现及治疗.结果 ITP患者肝炎病毒(HBV,HCV)感染率为33.67%,患者出血倾向高.结论肝炎病毒感染可能是诱发ITP的病毒之一,肝炎病毒复制的患者糖皮质激素治疗受到限制,因此,在抗病毒基础上联合糖皮质激素治疗效果更好.

Objective To investigate the relationship between viral hepatitis( B,C) infection and primary immune thrombocytopenia( ITP),the clinical features of ITP patients with hepatitis virus infection,and their effects on the treatment and efficacy of ITP patients.Method A total of 98 patients with ITP were enrolled.The enzyme-linked immunosorbent assay( ELISA) method was used to detect HBV and HCV serum markers.General information,clinical presentation and treatment of the hepatitis( B,C) infection group and negative control group were analyzed and compared.Results The infection rate of hepatitis virus( HBV,HCV) in ITP patients was 33.67%,the bleeding tendency of virus infection group was higher.Conclusion Hepatitis virus infection may be one of the viruses that induce ITP. The treatment of glucocorticoids in patients with hepatitis virus replication is limited,therapy combining with glucocorticoids on the basis of anti-viral is effective.