腹腔镜胰体尾切除治疗神经内分泌肿瘤单中心研究

A single institution study of laparoscopic pancreatectomy for pancreatic neuroendocrine tumor in body and tail of pancreas

目的:探讨腹腔镜手术治疗胰体尾部神经内分泌肿瘤的可行性及安全性。方法:回顾分析2015年8月至2019年6月收治的20例胰体尾部神经内分泌肿瘤行腹腔镜胰体尾切除术患者的临床资料,按肿瘤大小匹配(1:2)胰体尾神经内分泌肿瘤行开放胰体尾切除术的患者资料进行对比分析。结果:开放组与腹腔镜组手术时间差异无统计学意义(P>0.05),腹腔镜组出血量、术后疼痛评分、术后住院时间、术后首次排气时间、开放饮食时间、下床活动时间及引流管拔除时间优于开放组(P<0.05)。开放组与腹腔镜组总体并发症发生率(55%vs.40%)差异无统计学意义(P>0.05)。结论:腹腔镜手术治疗胰体尾神经内分泌肿瘤创伤小、康复快,安全、可行,可使患者获益。

Objective:To investigate the therapeutic safety and effect of laparoscopic surgery for neuroendocrine tumor in the body and tail of pancreas.Methods:A retrospective study was performed on the clinical data of 20 patients with neuroendocrine tumor operated by laparoscopic surgery in the body and tail of pancreas,matched with 40 patients operated with open procedure.Results:There were no significant differences between the two groups in the operating time(P>0.05),blood loss,VAS score,duration of hospital stay,time for initial water/food intake,initial exhaust and initial out-of-bed activity,time of abdominal drainage-tube removal in the laparoscopic group were all significantly reduced when compared with the open surgery group(P<0.05).The rate of postoperative complications in the laparoscopic group was 40%,while it was 55%in the open group with no statistical difference(P>0.05).Conclusions:Laparoscopic surgery is mini-invasive,safe and effective for neuroendocrine neoplasm in body and tail of pancreas,and of benefit to the patients.