神经节苷脂联合还原型谷胱甘肽治疗新生儿缺氧缺血性脑病的效果

Effect of Ganglioside Combined with Reduced Glutathione on Neonatal Hypoxic Ischemic Encephalopathy

目的探究新生儿缺氧缺血性脑病患者接受神经节苷脂与还原型谷胱甘肽联合治疗的效果。方法回顾性分析2013年1月至2017年12月新生儿缺氧缺血性脑病患者60例为研究对象,以中心随机化法分为两组,每组30例。对照组行神经节苷脂治疗,实验组行神经节苷脂与还原型谷胱甘肽联合治疗。比较两组治疗的效果、症状消失时间、不良反应发生率。结果实验组的总有效率明显高于对照组(96.67%vs.80.00%,P<0.05);实验组肌张力、意识障碍、惊厥消失时间均短于对照组(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论新生儿缺氧缺血性脑病患者接受神经节苷脂与还原型谷胱甘肽联合治疗,安全有效。

Objective To investigate the effect of ganglioside combined with reduced glutathione on neonatal hypoxic-ischemic encephalopathy(HIE).Methods Sixty neonatal HIE patients from January 2013 to December 2017 were selected and divided into two groups by central randomization,30 per groups.The control group was treated with ganglioside,and the experimental group was treated with ganglioside combined with reduced glutathione.The total effective rate,disappearance time of symptoms,and incidence of adverse reactions in the two groups were compared.Results The total effective rate of the experimental group was significantly higher than that of the control group(96.67%vs.80.00%,P<0.05).The disappearance time of symptoms(muscle tone,disturbance of consciousness,convulsion)in the experimental group was shorter than that in the control group(P<0.05).The incidence of adverse reactions in the two groups was not statistically significant(P>0.05).Conclusion It was safe and effective for neonatal HIE patients to receive ganglioside and reduced glutathione combined treatment.