大环内酯类抗菌药物辅助治疗肺部铜绿假单胞菌感染效果

Effect of macrolide antibiotics on pulmonary infection of Pseudomonas aeruginosa

目的观察大环内酯类抗菌药物辅助治疗肺部铜绿假单胞菌(PA)感染患者的临床效果以及安全性。方法选取湖北省荆门市第一人民医院2017年8月至2019年2月收治的62例PA感染患者,采用数字奇偶法分为两组,每组31例。对照组采用左氧氟沙星+头孢他啶药物进行治疗,实验组采用左氧氟沙星+头孢他啶+大环内酯类抗菌药物治疗。用药5周后对比两组治疗效果效果。结果实验组治疗总有效率(93.55%)显著高于对照组(74.19%),差异有统计学意义(P<0.05)。实验组不良反应发生率(12.92%)与对照组(6.46%)比较,差异无统计学意义(P>0.05)。结论PA感染患者在接受左氧氟沙星+头孢他啶药物治疗基础上,选择大环内酯类抗菌药物进行辅助治疗,可显著提高治疗效果,且对用药安全性无显著影响。

Objective To observe the clinical efficacy and safety of macrolide antibiotics in the treatment of Pseudomonas aeruginosa(PA)infection in the lung.Methods A total of 62 patients with PA infection who were admitted to the First People's Hospital of Jingmen City,Hubei Province from August 2017 to February 2019 were divided into two groups,31 in each group.The control group was treated with levofloxacin+ceftazidime,and the experimental group was treated with levofloxacin+ceftazidime+macrolide antibiotics.After 5 weeks of treatment,the effects of the two groups were compared.Results The total effective rate of the experimental group(93.55%)was significantly higher than that of the control group(74.19%),and the difference was statistically significant(P<0.05).The incidence of adverse reactions in the experimental group(12.92%)was not significantly different from that in the control group(6.46%)(P>0.05).Conclusion Based on the treatment of levofloxacin+ceftazidime,patients with PA infection should choose macrolide antibiotics for adjuvant treatment,which can significantly improve the therapeutic effect and has no significant effect on the safety of medication.