1例柳氮磺吡啶致严重粒细胞缺乏的案例分析

A Case Analysis of Serious Agranulocytosis Caused by Sulfasalazine

目的探讨柳氮磺吡啶致严重粒细胞缺乏的临床特点、诊疗原则和药学监护。方法通过回顾国内外关于柳氮磺吡啶致严重粒细胞缺乏的文献报道,分析患者的临床表现、诊疗策略及用药方案。结果该患者在使用柳氮磺吡啶数天后引起粒细胞下降,停药后,仍呈现持续下降的趋势。在予以对症处理后,患者在11 d后粒细胞恢复至正常范围。结论对于使用柳氮磺吡啶出现粒细胞缺乏的患者,应根据患者病情、用药史及粒细胞缺乏特点,准确判断原因并及时处理,因症施治,确保患者用药安全。

OBJECTIVE To investigate the clinical features,diagnosis,treatment principles and pharmaceutical care of agranulocytosis caused by sulfasalazine.METHODS The diagnosis and treatment of a patient with agranulocytosis caused by sulfasalazine was analyzed by reviewing the literatures about sulfasalazine-induced agranulocytosis.RESULTS Sulfasalazine could cause a drop in leucocytes and neutrophils within several days of administration.The leucocytes in this patient still showed a trend of continuous decline after sulfasalazine withdrawal and was restored to normal range on the eleventh day after treating it accordingly.CONCLUSION For patients with agranulocytosis caused by sulfasalazine,the cause of agranulocytosis should be figured out exactly and treated timely and correctly according to patients’conditions,medical histories to ensure the medical safety.