盐酸多奈哌齐辅助治疗老年性痴呆的疗效观察

Therapeutic Effect of Donepezil Hydrochloride on Senile Dementia

目的分析老年性痴呆患者采用盐酸多奈哌齐辅助治疗的临床效果。方法选取2017年5月至2019年3月西安北环医院86例老年性痴呆患者,随机分为对照组(43例)和观察组(43例)。其中,对照组采用吡拉西坦片进行治疗,观察组给予盐酸多奈哌齐治疗,比较两组患者疗效。结果治疗前,两组患者MMSE评分比较,差异无统计学意义(P>0.05);治疗后观察组患者MMSE评分高于对照组,差异有统计学意义(P<0.05);治疗前两组患者ADL评分比较,差异无统计学意义(P>0.05);观察组治疗后ADL分值高于对照组,差异有统计学意义(P<0.05);观察组患者临床治疗总有效率高于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论对老年性痴呆患者采用盐酸多奈哌齐治疗能取得良好效果,尤其体现在认知功能的改善、日常生活自理能力的提升等方面,可有助于提高患者临床治疗效果。

Objective To analyze the clinical effect of adjuvant treatment with donepezil hydrochloride in patients with senile dementia.Methods 6 patients with senile dementia from Xi'an Beihuan Hospital from May 2017 to March 2019 were randomly divided into control group(43 cases)and observation group(43 cases).Among them,the control group was treated with piracetam tablets,and the observation group was treated with donepezil hydrochloride.The efficacy of the two groups was compared.Results Before treatment,there was no significant difference in MMSE score between the two groups(P>0.05).After treatment,the MMSE score of the observation group was higher than that of the control group,the difference was statistically significant(P<0.05).There was no significant difference in ADL scores(P>0.05).The ADL scores in the observation group were higher than those in the control group(P<0.05).The total effective rate of clinical treatment in the observation group was higher than that in the control group.The difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The treatment of senile dementia with donepezil hydrochloride can achieve good results,especially in the improvement of cognitive function and the improvement of daily living self-care ability,which can help to improve the clinical treatment effect of patients.