低剂量非铂类联合化疗在老年晚期非小细胞肺癌治疗中的应用效果

Effect of Low-Dose Non-Platinum Combination Chemotherapy in Treatment of Elderly Patients with Aadvanced Non-Small Cell Lung Cancer

目的探讨低剂量非铂类联合化疗在老年晚期非小细胞肺癌治疗中的应用效果。方法选取玉林市红十字会医院2016年8月至2017年10月收治的80例老年晚期非小细胞肺癌患者,根据治疗方式不同,将其随机分为对照组与观察组,每组40例。对照组患者给予吉西他滨(或去甲长春花碱)联合顺铂治疗,而观察组患者采用吉西他滨与低剂量去甲长春花碱联合治疗。比较两组患者治疗效果及不良反应发生情况。结果两组患者治疗后总有效率比较,差异无统计学意义(P>0.05)。观察组患者治疗后KPS评分增高率高于对照组,差异有统计学意义(P<0.05)。两组患者治疗后骨髓抑制发生率比较差异无统计学意义(P>0.05);但观察组患者Ⅱ及Ⅲ度的消化道不良反应发生率明显低于对照组(P<0.05)。结论采用低剂量非铂类联合化疗方案治疗对老年晚期非小细胞肺癌患者效果明显,并且具有较高的安全性。

Objective To investigate the effect of low-dose non-platinum combination chemotherapy in the treatment of elderly patients with advanced non-small cell lung cancer(NSCLC).Methods Eighty elderly patients with advanced NSCLC admitted to Yulin Red Cross Hospital from August 2016 to October 2017 were randomly divided into control group and observation group,40 patients per group.The control group received gemcitabine(or vinorelbine)combined with cisplatin,while the observation group was treated with gemcitabine and lowdose vinorelbine.The therapeutic effects and adverse reactions of the two groups were compared after treatment.Results After treatment,there was no significant difference in the total effective rate between the two groups(P>0.05).The increase rate of KPS score in the observation group was higher than that in the control group(P<0.05).There was no significant difference in the incidence of myelosuppression between the two groups(P>0.05).However,the incidences of Ⅱ-and Ⅲ-degree digestive tract adverse reactions in the observation group were lower than those in the control group(P<0.05).Conclusion The treatment of low-dose non-platinum combination chemotherapy was effective and safe for elderly patients with advanced NSCLC.