丙戊酸镁缓释片联合新型抗精神病药治疗复发性躁狂症的疗效及对患者糖脂代谢的影响

Effect of Magnesium Valproate Sustained Release Tablets Combined with New Antipsychotics on Patients with Recurrent Mania and Impact on Glucose and Lipid Metabolism

目的观察丙戊酸镁缓释片联合新型抗精神病药治疗复发性躁狂症的疗效,及其对患者糖脂代谢的影响。方法选取2016年10月到2018年10月接受博兴县湖滨中心卫生院治疗的所有复发性躁狂症患者当中随机选取90例患者为研究对象,分为观察组和对照组,各45例。观察组给予丙戊酸镁缓释片联合新型抗精神病药进行治疗,对照组给予常规抗精神病药进行治疗。对比两组患者的治疗有效率,检测患者的空腹血糖、总胆固醇及甘油三酯情况。结果观察组患者的躁狂评分明显比对照组患者低(P<0.05);观察组患者治疗总有效率优于对照组(P<0.05)。观察组患者的空腹血糖、总胆固醇以及甘油三酯均明显高于对照组(P<0.05)。结论丙戊酸镁缓释片联合新型抗精神病药治疗复发性躁狂症,可降低患者的躁狂评分,显著提高临床治疗总有效率,同时提高患者的血糖和血脂代谢水平。

Objective To observe the efficacy of magnesium valproate sustained release tablets combined with new antipsychotic drugs in the treatment of recurrent mania and its effect on glucose and lipid metabolism.Methods From October 2016 to October 2018,90 patients with recurrent mania who received treatment in our hospital were randomly selected as study subjects,divided into observation group and control group,45 cases each.The observation group was treated with magnesium valproate sustained release tablets combined with new antipsychotics,while the control group was treated with conventional antipsychotics.The effective rate of treatment was compared between the two groups,and the fasting blood glucose,total cholesterol and triglyceride were measured.Results After treatment,fasting blood glucose,total cholesterol and triglyceride in the observation group were significantly higher than those in the control group(P<0.05).The manic score of the observation group was significantly lower than that of the control group(P<0.05).The total effective rate of the observation group was better than that of the control group(P<0.05).Conclusion Magnesium valproate sustained-release tablets combined with new antipsychotics in the treatment of recurrent mania can reduce the manic score of patients,significantly improve the total effective rate of clinical treatment,and improve the level of blood glucose and blood lipid metabolism.