孕激素辅助治疗术后高危型子宫内膜癌的临床效果

Clinical and Pathological Evaluation of Adjuvant Progesterone-assisted Therapy for High-risk Endometrial Cancer after Operation

目的评价孕激素辅助治疗术后高危型子宫内膜癌的临床效果。方法选取2016年1月至2019年1月江苏大学附属医院妇科进行治疗的子宫内膜癌患者32例,随机分为普通组和实验组,每组16例。两组患者均行手术治疗,术后普通组行常规治疗,实验组行孕激素辅助治疗。比较两组患者的并发症发生率及白介素6(IL-6)、肿瘤坏死因子(TNF-α)、糖蛋白(CA125水平)。结果实验组并发症总发生率较普通组更低,差异有统计学意义(6.25%vs.37.50%,P<0.05)。实验组的IL-6、TNF-α、CA125水平较普通组更低,差异有统计学意义(P<0.05)。结论通过对高危型子宫内膜癌患者进行孕激素受体辅助治疗,可有效改善患者炎性因子水平,降低并发症发生率。

Objective To evaluate the effect of progesterone-assisted therapy for high-risk endometrial cancer after operation.Methods Thirty-two patients with endometrial cancer who were treated in our hospital from January 2016 to January 2019 were randomly divided into the general group and the experimental group,16 in each group.All patients in the two groups underwent surgery,the general group was treated with routine treatment after operation,and the experimental group was treated with progesterone.The incidence of complications and the levels of IL-6,TNF-alpha and CA125 in the two groups were compared.Results The total incidence of complications in the experimental group was lower than that in the general group,with statistical significance(6.25%vs.37.50%,P<0.05).The levels of IL-6,TNF-alpha and CA125 in the experimental group were lower than those in the general group,and the difference was statistically significant(P<0.05).Conclusion The progesterone receptor-assisted therapy for high-risk endometrial cancer patients can effectively improve the levels of inflammatory factors,and reduce the incidence of complications.