甲泼尼龙琥珀酸钠与醋酸泼尼松对肾移植后肺部感染的临床疗效比较

Comparison of Clinical Effect of Methylprednisolone Sodium Succinate and Prednisone Acetate on Pulmonary Infection after Renal Transplantation

目的比较甲泼尼龙琥珀酸钠静脉滴注与醋酸泼尼松口服对肾移植后肺部感染的临床疗效。方法选取2015年10月至2018年10月苏州大学附属第一医院接受肾移植治疗后肺部感染的患者66例,将患者按随机数字表法分为对照组(33例)和观察组(33例),对照组行醋酸泼尼松口服治疗,观察组行甲泼尼龙琥珀酸钠静脉滴注治疗。比较两组患者的临床疗效、动脉血氧分压。结果治疗后,观察组与对照组患者的存活例数、死亡例数对比,差异无统计学意义(P>0.05)。治疗后,两组患者动脉血氧分压水平均明显升高(P<0.05);在治疗2 d后,观察组患者的动脉血氧分压水平明显高于对照组(P<0.05)。结论肾移植后肺部感染患者接受甲泼尼龙琥珀酸钠治疗,可以快速改善患者肺部感染的症状。

Objective To compare the clinical effects of intravenous infusion of methylprednisolone sodium succinate and oral prednisone acetate for pulmonary infection after renal transplantation.Methods Sixtysix patients with pulmonary infection after renal transplantation in the First Affiliated Hospital of Suzhou University from October 2015 to October 2018 were randomly divided into control group(33 cases)and observation group(33 cases).The control group was treated with prednisone acetate orally and the observation group was treated with intravenous drip of methylprednisolone sodium succinate.The clinical effect and arterial oxygen partial pressure level were compared between the two groups.Results After treatment,there was no significant difference in the number of survivors and deaths between the two groups(P>0.05).After treatment,the arterial oxygen partial pressure levels were significantly increased in both groups(P<0.05);after treatment for 2 days,the arterial oxygen partial pressure level of the observation group was significantly higher than that of the control group(P<0.05).Conclusion Patients with pulmonary infection after renal transplantation receiving methylprednisolone sodium succinate can rapidly improve the symptoms of lung infection in patients.