阿奇霉素联合头孢类药物治疗慢性阻塞性肺疾病急性加重期的疗效评价

Efficacy Evaluation of Azithromycin Combined with Cephalosporins in the Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease

目的探讨阿奇霉素联合头孢类药物治疗慢性阻塞性肺疾病急性加重期的临床疗效,为临床治疗提供参考。方法选取2018年2月至2019年2月临沂市兰山区康复医院收治的78例急性加重期慢性阻塞性肺疾病患者为研究对象,根据随机数字表法分为观察组和对照组,各39例。对照组患者接受常规治疗,观察组患者接受阿奇霉素及头孢类药物联合治疗,两组患者均持续治疗7 d。观察并比较两组临床疗效;治疗前后,检测并比较两组患者的肺功能指标水平,包括:第一秒用力呼气量占所有呼气量的比例(FEV1/FVC)、最大呼吸速度(PEF);观察并比较两组不良反应发生情况。结果对照组治疗总有效率为71.79%,显著低于观察组的94.87%,差异有统计学意义(P<0.05)。治疗前,两组FEV1/FVC、PEF水平比较,差异无统计学意义(P>0.05);治疗后,两组FEV1/FVC、PEF水平均高于本组治疗前,且观察组高于对照组,差异有统计学意义(P<0.05)。两组均未发生明显不良反应。结论慢性阻塞性肺疾病急性加重期患者采取阿奇霉素联合头孢类药物治疗效果显著。

Objective To investigate the clinical efficacy of azithromycin combined with cephalosporins in the treatment of acute exacerbation of chronic obstructive pulmonary disease,and to provide reference for clinical treatment.Methods A total of 78 patients with acute exacerbation of chronic obstructive pulmonary disease admitted to the Rehabilitation Hospital of Lanshan District,Linyi City from February 2018 to February 2019 were enrolled.According to the random number table method,the observation group and the control group were divided into 39 cases.Patients in the control group received routine treatment.Patients in the observation group received a combination of azithromycin and cephalosporin.Both groups continued treatment for 7 days.The clinical efficacy of the two groups was observed and compared.Before and after treatment,the lung function index levels of the two groups were detected and compared,including the ratio of forced expiratory volume in the first second to the total expiratory volume(FEV1/FVC)and maximum respiratory rate(PEF).observed and compared the occurrence of adverse reactions in the two groups.Results The total effective rate of the control group was 71.79%,which was significantly lower than that of the observation group(94.87%).The difference was statistically significant(P<0.05).Before treatment,there was no significant difference in the levels of FEV1/FVC and PEF between the two groups(P>0.05).After treatment,the levels of FEV1/FVC and PEF in the two groups were higher than those in the group before treatment,and the observation group was higher than the control group.The difference was statistically significant(P<0.05).No significant adverse reactions occurred in either group.Conclusion Patients with acute exacerbation of chronic obstructive pulmonary disease have a significant effect on azithromycin combined with cephalosporins.