超脉冲CO2点阵激光联合山豆根治疗增生性瘢痕的疗效及对生活质量的影响

Clinical Effectiveness and Effects on the Quality of Life of Ultra Pulse CO2 Fractional Laser Combined Sophora Tonkinesis Gapnep in the Treatment of the Hypertrophic Scar

目的探讨超脉冲CO2点阵激光联合山豆根治疗增生性瘢痕的临床疗效及对生活质量的影响。方法选取收治于我院的58例增生性瘢痕患者为研究对象,并将其随机分为观察组和对照组,每组各29例。对照组予超脉冲CO2点阵激光治疗,观察组在此基础上配合山豆根治疗,比较2组治疗前后温哥华瘢痕量表(VSS)、北卡罗来纳大学(UNC)瘢痕量表、皮肤病生活质量指数(DIQL)变化,并观察2组患者的不良反应情况。结果经过治疗后,观察组和对照组VSS和UNC瘢痕量表显著低于同组治疗前,差异有统计学意义(P<0.05),且观察组比对照组下降更明显,2组间差异有统计学意义(P<0.05);2组DLQI评分较治疗前下降明显,差异有统计学意义(P<0.01)。结论利用超脉冲CO2点阵激光联合山豆根治疗增生性瘢痕可有效降低VSS、UNC瘢痕量表评分,取得较好的临床疗效,改善患者生活质量,且不良反应少。

Objective In order to investigate the clinical efficacy and effects on the quality of life of hypertrophic scars treated by ultra pulse CO2 fractional laser combined with Sophora tonkinesis Gapnep. Methods Fifty-eight patients with hypertrophic scar were selected and randomly divided into observation group and control group,twenty-nine cases in each group. The control group was treated with ultra pulse CO2 fractional laser,and the observation group on this basis with Sophora tonkinesis Gapnep treatment. The changes of Vancouver Scar Scale(VSS),University of North Carolina(UNC) Scar Scale and Dermatology Quality of Life Index(DIQL) were compared between the two groups,and the untoward effect of the two groups were observed. Results After treatment,the VSS and UNC scar scale of the observation group and the control group were significantly lower than those of the same group before treatment,the difference was statistically significant(P<0.05),and the observation group decreased more significantly than the control group,the difference between the two groups was statistically significant(P <0.05);DLQI score of the two groups was decreased obviously than that before treatment,the differences were statistically significant(P<0.01);the rate of adverse reaction of the observation group was 6.90%,and the control group was 17.24%,the difference was statistically significant(P<0.05). Conclusion Ultra pulse CO2 fractional laser combined with Sophora tonkinesis Gapnep can effectively reduce the scores of VSS and UNC scar scale,achieve better clinical efficacy,improve the quality of life of patients,and have fewer adverse reactions.