激素联合免疫抑制剂治疗风湿性疾病合并乙肝患者的临床疗效研究

Clinical Efficacy of Hormone Combined with Immunosuppressive Agents in the Treatment of Patients with Rheumatic Diseases Complicated with Hepatitis B

目的 探究风湿性疾病合并乙肝患者的治疗中采用激素联合免疫抑制剂治疗的临床效果。方法 方便选取该院2013年1月-2018年1月该院收治的风湿性疾病合并乙肝患者400例,依据随机数字表法将患者分为对照组和观察组,每组200例患者,对照组采用小剂量激素、环孢素治疗,观察组在对照组的基础上加用拉夫米定治疗,比较两组的临床疗效。结果 经治疗后,观察组GGT(30.04±2.41)U/L、ALT(18.01±2.24)U/L、AST(19.43±2.52)U/L的值均较对照组低GGT (41.23±5.46)U/L、ALT (35.87±4.58)U/L、AST (37.27±5.48)U/L,差异有统计学意义(t=26.516, 49.540,41.829,P<0.05);观察组HBV-DNA转阳率48.00%、HbeAg转阳率44.00%显著较对照组HBV-DNA转阳率78.00%、HbeAg转阳率76.50%低,差异有统计学意义(χ^2=38.010, 44.103,P<0.05)。结论 在对风湿性疾病合并乙肝患者的治疗中采用激素联合免疫抑制剂治疗的效果更佳,有效降低患者的肝功能指标和HBV-DNA转阳率、HbeAg转阳率,临床疗效较好。

Objective To investigate the clinical effects of hormone combined immunosuppressive therapy in the treatment of patients with rheumatic diseases and hepatitis B.Methods Convenient selected a total of 400 patients with rheumatic diseases and hepatitis B admitted to the hospital from January 2013 to January 2018 were enrolled.The patients were divided into the control group and the observation group according to the random number table method.Each group of 200 patients and the control group.The patients in the observation group were treated with low-dose hormone and cyclosporine,and the observation group was treated with lovastatin.The clinical effects of the two groups were compared.Results After treatment,the GGT(30.04±2.41)U/L,ALT(18.01±2.24)U/L,and AST(19.43±2.52)U/L values in the observation group were lower than those in the control group(41.23±5.46)U/L,ALT(35.87±4.58)U/L,AST(37.27±5.48)U/L,the difference was statistically significant(t=26.516,49.540,41.829,P<0.05);observation group HBV-DNA transfer positive rate of 48.00%and the HBeAg conversion rate of 44.00%were significantly lower than the control group's HBV-DNA conversion rate of 78.00%and HbeAg conversion rate of 76.50%.The difference was statistically significant(χ^2=38.010,44.103,P<0.05).Conclusion In the treatment of patients with rheumatic diseases complicated with hepatitis B,the effect of hormone combined immunosuppressive therapy is better,and the liver function index,HBV-DNA conversion rate and HBeAg conversion rate are effectively reduced,and the clinical curative effect is better.