艾拉莫德联合补肾强督汤及督灸在肾虚督寒型强直性脊柱炎中的应用效果

Effect of Iguratimod Tablet Combined with Bushen Qiangdu Decoction and Du Meridian Moxibustion in Patients with Ankylosing Spondylitis

目的 探讨艾拉莫德联合补肾强督汤及督灸下调肾虚肾寒型强直性脊柱炎患者中的应用效果及对肿瘤坏死因子-a(TNF-a)、白细胞介素-6(IL-6)的影响。方法 选取烟台市中医医院收治的62例肾虚肾寒型强直性脊柱炎患者作为研究对象,分为对照组(30例)和观察组(32例)。对照组采用艾拉莫德治疗,观察组联合补肾强督汤及督灸治疗,比较两组临床效果及对患者TNF-a、IL-6的影响。结果 观察组治疗后4个月TNF-a、IL-6水平,均低于对照组(P <0.05);观察组治疗后疼痛改善时间、晨僵时间,均短于对照组(P <0.05);观察组腰背活动度增加量大于对照组(P <0.05);两组不良反应发生率差异无统计学意义(P> 0.05)。结论 艾拉莫德联合补肾强督汤及督灸用于肾虚肾寒型强直性脊柱炎患者中能降低炎症因子水平,安全性较高。

Objective To explore the application effect of Iguratimod Tablet combined with kidney-tonifying and regulating moxibustion in patients with kidney-deficiency cold-type ankylosing spondylitis.Methods A total of 62 cases of kidney-deficiency cold-type ankylosing spondylitis treated Yantai Hospital of Traditional Chinese Medicine from May 2016 to March 2018 were selected as study objects,divided into control group(30 cases)and observation group(32 cases).The control group was treated with Iguratimod Tablet,and the observation group was combined with kidney-tonifying and Du meridian moxibustion.The clinical effects of the two groups and the effects on patients TNF-a and IL-6 were compared between groups.Results TNF-a and IL-6 levels in the observation group were all lower than those in the control group at 4 months after treatment(P<0.05).The improvement time of pain and morning stiffness in the observation group were shorter than those in the control group(P<0.05).The increase of lumbar back activity in the observation group was greater than that in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Iguratimod Tablet combined with kidney-tonifying and Du meridian moxibustion can reduce the level of inflammatory factors in patients with kidney-deficiency cold-type ankylosing spondylitis with high safety.