不同浓度一氧化氮吸入治疗新生儿持续性肺动脉高压的疗效及安全性分析

Efficacy and Safety of Inhaled Different Concentrations of Nitric Oxide NO in the Treatment of Neonatal Persistent Pulmonary Hypertension PPHN

目的 探究吸入不同浓度一氧化氮治疗新生儿持续性肺动脉高压(PPHN)的临床疗效。方法 选取2016年6月至2018年8月河北省邯郸市妇幼保健院收治的52例PPHN新生儿根据治疗方法的不同分为对照组、NO低剂量组(10~45 ppm)和NO高剂量组(20~65 ppm),分析其临床效果。结果 低剂量组、高剂量组患儿治愈率均显著高于对照组(P <0.05),死亡率显著地下降(P <0.05)。结论 吸入NO治疗能够有效地缓解患儿呼吸困难症状,但低剂量与高剂量之间差异不显著,高剂量可增加出血风险,因可用低剂量NO治疗PPHN。

Objective To investigate the clinical effect of inhaling different concentrations of nitric oxide in the treatment of neonatal persistent pulmonary hypertension.Methods Fifty-two cases of PPHN newborns who were treated in our hospital from June 2016 to August 2018 were divided into control group,NO low-dose group(10~45 ppm)and NO high-dose group(20~65 ppm)according to different treatment methods.The clinical effects were analyzed.Results The cure rates of the low-dose group and the high-dose group respectively,which were significantly higher than the control group(P<0.05),and the mortality was significantly decreased(P<0.05).Conclusion Inhaled NO treatment can effectively alleviate the symptoms of dyspnea in children,but the difference between low dose and high dose is not significant.High-dose NO can increase the risk of bleeding,therefore low-dose of NO can be used to treat PPHN.