高通量血透对尿毒症患者血管内皮功能的影响

Effect of High Flux Hemodialysis on Vascular Endothelial Function in Uremic Patients

目的 分析高通量血透对尿毒症患者血管内皮功能的影响。方法 选取2016年6月至2018年1月贵阳市第二人民医院收治的20例行高通量血透治疗的尿毒症患者,治疗前后,均进行心脏超声检测、动脉内皮功能检测。结果 治疗后,所有患者心脏功能、动脉内皮功能、各项生化指标均明显改善,治疗前后比较差异有统计学意义(P <0.05)。结论 高通量血透可有效改善尿毒症患者的心脏舒张功能,延缓血管内皮功能的损害,同时还可有效清除大分子毒素、炎症介质,改善患者脂质代谢功能。

Objective To analyze the application of high flux hemodialysis in the treatment of uremia patients and its effect on vascular endothelial function.Methods Twenty uremic patients treated with high flux hemodialysis in our hospital from June 2016 to January 2018 were selected.Before and after treatment,echocardiography and arterial endothelial function were detected.Result After treatment,cardiac function,arterial endothelial function and biochemical indexes of all patients were significantly improved,and the difference before and after treatment was statistically significant(P<0.05).Conclusion High flux hemodialysis can effectively improve the cardiac diastolic function and delay the damage of vascular endothelial function in uremic patients.It can also effectively remove macromolecule toxins and inflammatory mediators and improve the lipid metabolism function of patients.