曲安奈德口腔软膏治疗充血糜烂型口腔扁平苔藓患者的临床疗效及安全性观察

Clinical Effect and Safety of Triamcinolone Acetonide Dental Paste in Treatment of Patients with Hyperemic Erosive Oral Lichen Planus

目的 研究曲安奈德口腔软膏治疗充血糜烂型口腔扁平苔藓(EOLP)患者的临床疗效及安全性。方法 选取2017年8月至2018年8月解放军904医院治疗的62例EOLP患者,采用抽签法分为观察组及对照组,每组31例。两组患者均采用常规药物对症治疗,观察组患者加用曲安奈德口腔软膏。比较两组患者的临床疗效、病损面积/黏膜情况评分及VAS评分,观察两组用药安全。结果观察组临床总有效率明显高于对照组高(96.77%vs. 74.19%,P <0.05)。治疗后,两组患者的病损面积/黏膜情况评分及VAS评分均显著低于治疗前(P <0.05),且观察组评分均较对照组更低(P <0.05)。用药后两组患者经血常规、肝肾功能检查及血糖水平检查,均未发生任何异常。观察组患者检出3例唾液真菌(9.68%),对照组患者检出2例唾液真菌(6.45%),两组比较,差异无统计学意义(P> 0.05)。结论 曲安奈德口腔软膏治疗EOLP患者安全有效。

Objective To study the clinical effect and safety of Triamcinolone Acetonide Dental Paste(TADP)in the treatment of patients with hyperemic erosive oral lichen planus(EOLP).Methods Sixty-two patients with EOLP treated in PLA 904 Hospital from August 2017 to August 2018 were selected and divided into the observation group and the control group,31 cases per group.ALL patients in both groups were treated with conventional drug treatment.The patients in the observation group were additionally given TADP.The clinical effects,lesion area/mucosal score and VAS score of the two groups were compared.The safety in both groups were observed.Results The therapeutic total effective rate of the observation group was significantly higher than that of the control group(96.77%vs.74.19%,P<0.05).After treatment,the lesion area/mucosa score and VAS score of the two groups were significantly lower than those before treatment(P<0.05),and the scores in the observation group were significantly lower than the control group(P<0.05).After treatment,the patients in the two groups had no abnormalities in blood routine,liver and kidney function tests and blood glucose levels.Three patients with salivary fungi(9.68%)were detected in the observation group,and 2 patients(6.45%)were found in the control group.There was no significant difference between the two groups(P>0.05).Conclusion TADP was effective and safe in the treatment of patients with EOLP.