TACE治疗对肝细胞性肝癌患者ALT、AFP水平的影响及MRI对患者预后的评价

Effect of TACE on ALT and AFP Levels and Prognostic Value of MRI in Patients with Hepatocellular Carcinoma

目的探析经导管动脉化学栓塞(TACE)治疗对肝细胞性肝癌(HCC)患者谷丙转氨酶(ALT)、甲胎蛋白(AFP)水平的影响及MRI对患者预后价值。方法选取滨州市中心医院于2013年1月至2018年1月收治的50例进行TACE治疗的HCC患者的临床资料。比较治疗前后患者肝功能及AFP水平差异;观察MRI病灶信号情况、肿瘤残留复发强化特点。结果治疗后HCC患者的ALT、AST、及AFP水平均低于治疗前(P<0.01);碘油沉积区T1WI、T2WI均以低信号为主。延迟局部强化T2WI为高信号,T1WI为低信号。MRI增强扫描有34个呈现速升速降型,其他为短T1WI长T2WI高信号。结论TACE能够减轻HCC患者肝损伤,MRI检测有利于患者预后。

Objective To investigate the effect of transcatheter arterial chemoembolization(TACE)on ALT and AFP levels and the prognostic value of MRI in patients with hepatocellular carcinoma(HCC).Methods The clinical data of 50 patients with HCC treated with TACE from January 2013 to January 2018 were selected.The difference of liver function and AFP level was compared before and after treatment,and the signal intensity of the lesion and the enhancement of residual tumor recurrence were observed.Results After treatment,the levels of ALT,AST and AFP in HCC patients were significantly lower than those before treatment(P<0.01).T1WI and T2WI in iodized oil deposits were mainly low signal.Delayed local enhancement showed a high signal on T2WI and a low signal on T1WI.On contrast-enhanced MR scans,34 cases showed rapid increase and decrease,while the others showed high signal intensity on short T1WI and long T2WI.Conclusion TACE can alleviate liver injury in patients with HCC,and MRI is helpful for prognosis.