三七叶总皂苷对中枢神经系统的作用研究进展

Research progress on the effects of Total Saponins from Panax Notoginseng Leaves on central nervous system

三七茎叶的资源丰富,价廉,且尚未得到充分利用,研究发现三七茎叶富含糖类、黄酮类、三七叶总皂昔等化合物。其中三七叶总皂昔是三七茎叶的提取物,三七叶总皂昔毒性低,其功效日益受到瞩目,对心血管系统、对中枢神经系统、免疫功能、抗肿瘤及改善微循环等方面有良好的作用,临床应用越来越广泛。三七叶总皂昔中是人参皂昔Rbi、Rc、Rb2,Rbs对中枢神经系统有药理活性,其对中枢神经系统的作用包括抗抑郁、改善睡眠、镇痛及镇静这几个作用。本文从三七叶总皂昔抗抑郁、改善睡眠、镇痛及镇静这几方面综述其对中枢神经系统的作用的研究进展。

the stem and leaves of panax notoginseng are rich in resources,cheap in price,and have not been fully utilized.Studies have found that the stem and leaves of panax notoginseng are rich in compounds such as sugars,flavonoids and total saponins of panax notoginseng.Among them,the total saponins of panax notoginseng leaves are extracts from the stems and leaves of panax notoginseng.The low toxicity of the total saponins of panax notoginseng leaves has attracted increasing attention,and it has good effects on cardiovascular system,central nervous system,immune function,antitumor and improvement of microcirculation,etc.,and has been widely used in clinical practice.Ginsenosides Rbl,Rc,Rb2 and Rb3 have pharmacological activities on the central nervous system,and th&r effects on the central nervous system include anti-depression,sleep improvement,analgesia and sedation.This article reviews the research progress on the effects of total saponins from panax notoginseng leaves on central nervous system from the aspects of anti-depression,sleep improvement,analgesia and sedation.