摘要
褪黑激素是一类具有多种功能的激素,可通过结合特定受体,激活一系列复杂的信号通路,发挥心脏缺血/再灌注损伤的保护效应。本综述主要对褪黑激素受体、褪黑激素诱导心肌保护的可能作用机制、以及褪黑激素的药物应用和临床研究等进行简要概述。
Melatonin,a hormone with multiple functions,can activate a vast array of complex signaling pathways by binding specific receptors,thus protecting the heart against ischemia/reperfusion injury.This review summarizes on the melatonin receptors,the probable mechanism of melatonin-induced myocardial protection,and its therapeutic application and clinical research.
作者
徐虎
范利
曹丰
XU Hu;FAN Li;CAO Feng(Department of Cardiology,Second Medical Center,Chinese PLA General Hospital,Beijing 100853,China;Second Medical Center,Chinese PLA General Hospital,Beijing 100853,China;National Clinical Research Center for Geriatric Diseases,Chinese PLA General Hospital,Beijing 100853,China;Translational Medicine Center,Chinese PLA General Hospital,Beijing 100853,China)
出处
《中华老年多器官疾病杂志》
2019年第11期872-876,共5页
Chinese Journal of Multiple Organ Diseases in the Elderly
基金
军队保健专项科研课题(18BJZ32)
解放军总医院医疗大数据研发项目(2017MBD-008)
解放军总医院成果转化课题(2017TM-003)~~
关键词
受体
褪黑激素
心肌缺血
再灌注损伤
心肌保护
receptor
melatonin
myocardial ischemia
reperfusion injury
myocardial protection
