摘要
[Objectives]To study the effects of Fruticosa potentilla L.on the expression of key enzymes and hormones related to glucose and lipid metabolism in T2DM rats.[Methods]The ethyl acetate fraction of 95%methanol extract of F.potentilla(MEE)was administered orally to the T2DM rats,and the level of glucose and expression of insulin,resistin,leptin,glucokinase(GK)and glucose-6-phosphatase(G-6-Pase)in the rats were measured and detected.[Results]In the T2DM rats administered with MEE,the postprandial blood glucose level decreased,the expression levels of resistin,leptin and G-6-Pase were down-regulated,and the expression levels of insulin and GK were up-regulated(P<0.05,P<0.01).[Conclusions]F.potentilla can reduce effectively postprandial blood glucose level,regulate the expression of a variety of enzymes and hormones related to glucose and lipid metabolism and recover partially the insulin level in T2DM rats to achieve resistance to T2DM.
[Objectives] To study the effects of Fruticosa potentilla L. on the expression of key enzymes and hormones related to glucose and lipid metabolism in T2 DM rats. [Methods] The ethyl acetate fraction of 95% methanol extract of F. potentilla(MEE) was administered orally to the T2 DM rats, and the level of glucose and expression of insulin, resistin, leptin, glucokinase(GK) and glucose-6-phosphatase(G-6-Pase) in the rats were measured and detected. [Results] In the T2 DM rats administered with MEE, the postprandial blood glucose level decreased, the expression levels of resistin, leptin and G-6-Pase were down-regulated, and the expression levels of insulin and GK were up-regulated(P<0.05, P<0.01).[Conclusions] F. potentilla can reduce effectively postprandial blood glucose level, regulate the expression of a variety of enzymes and hormones related to glucose and lipid metabolism and recover partially the insulin level in T2 DM rats to achieve resistance to T2 DM.
基金
Supported by National Natural Science Foundation of China(No.81460652)
Key Research and Development and Achievements Transformation Program of Qinghai Province(No.2018-SF-144)
Project Funded by Key Laboratory of Medicinal Animal and Plant Resources of Qinghai-Tibet Plateau in Qinghai Province(No.2017-z-y25)
