D3胚玻璃化冻融周期的临床结局分析

Clinical outcomes analysis of D3 embryo transfer in vitrification frozen thawed cycles

目的探讨分析D3胚玻璃化冻融移植与新鲜周期相比对临床妊娠和新生儿围产期情况的影响。方法将D3胚移植周期分为新鲜组和玻璃化冻融组,分析两组的临床妊娠情况(妊娠率、胚胎着床率、多胎妊娠率、早期和中晚期流产率、异位妊娠率、报婴回家率)及新生儿围产期状况(双胎率,剖宫产率,早产率以及男女性别比,胎龄、出生体重、出生身长、低体重、极低体重、巨大儿)。结果玻璃化冻融周期组的剖宫产率极显著高于新鲜周期组(P<0.01);双胎新生儿的出生体重,身长显著高于新鲜移植周期组,低体重率显著低于新鲜周期组(P<0.05),而单胎新生儿的低体重率显著高于新鲜移植周期(P<0.05);其他指标的比较无统计学差异。结论D3胚玻璃化冻融移植与新鲜周期移植的临床妊娠结局相似;玻璃化冻融周期的剖宫产发生率较高,其双胎新生儿体格评估指标优于新鲜周期,但单胎新生儿的低体重率发生率高于新鲜周期。

Objecyive:To explore the effects of frozen thawed D3 embryo transfer on clinical pregnancy and perinatal condition of newborn compared with fresh cycle.Metheds:The D3 embryo transfer cycles were divided into two groups,fresh group and vitrification frozen thaw group.The clinical pregnancy(the rates of clinical pregnancy,implantation,multiple pregnancy,early abortion,intermediate and late stage abortion,ectopic pregnancy,live birth)and perinatal condition of newborn(twins rate,caesarean delivery rate,preterm birth rate,male-female ratio,gestational age,birth weight,birth length,low birth weight infants,very low birth weight infants,fetal macrosomia)were analysed respectively.Result:The rate of caesarean delivery in vitrification frozen thaw group was significantly higher than that in the fresh group(P<0.01);The birth weight and birth length of twin newborns were significantly higher than that in the fresh group(P<0.05),and the rate of low birth weight in twin newborns was significantly lower than that in the fresh group,but the rate of low birth weight in singleton infants was significantly higher than that in the fresh group(P<0.05).As to other indicators,there were no significantly differences in two groups.Conclusion:The clinical pregnancy outcomes of D3 embryo transfer in vitrification frozen thawed cycles were similar to that in fresh cycles.The vitrification frozen thawed cycles have a higher rate of caesarean delivery,its physical evaluation indicators in twin newborns is superior to fresh cycles,but its rate of low birth weight in singleton infants is higher than fresh cycles.