胰腺癌与炎症的关系及其诊疗一体化应用研究进展

The inflammatory mechanism of pancreatic cancer and its theranostic significance

胰腺癌是一种起病隐匿、进展较快、预后极差的常见消化系统肿瘤。胰腺癌对常规的化疗和放疗均不敏感,因此,早期发现、早期治疗就显得尤为重要。炎症反应与胰腺癌的发生、发展有着密切的联系,胰腺慢性无菌性炎症是胰腺癌最主要的危险因素之一。故对炎性反应的研究对于胰腺癌的诊断、治疗、预后判断均有着重要的指导意义。近年来纳米技术在肿瘤诊疗中的研究进展愈加深入,对于胰腺癌的诊疗一体化有着重要的价值。作者重点讨论炎症反应与胰腺癌发生发展的关系及其诊疗一体化领域的研究进展。

It is well known that pancreatic ductal adeno-carcinoma(PDAC) is a highly aggressive malignancy with very poor prognosis, and most were first diagnosed with local advancement or metastasis. Considering its poor response to traditional chemotherapy and radiotherapy, it is crucial that the patients can be diagnosed and treated at an early stage. Inflammation has a tight relationship with tumorigenesis and tumor progression, and chronic aseptic inflammation of pancreas is one of the most important risk factors of pancreatic cancer. As nanotechnology shows great promise against malignant diseases like pancreatic cancer, more and more researches were conducted to exploit the characteristics of nanocarriers for their application in both diagnosis and treatment of malignancies. In this review, we summarize the role of inflammation in PDAC and its significance to both diagnostic and therapeutic strategies.