摘要
以2,6-二氯苯腈为原料,环丁砜为溶剂,通过与氟化钾进行氟代反应制得2,6-二氟苯腈,含量大于99%,收率90%.该工艺简便,氟代反应不使用催化剂,生产成本低、收率高,适合工业化生产.
2,6-Difluorobenzenitrile was synthesized from 2,6-dichlorobenzenitrile by fluorination reaction with potassium fluoride in sulfolane as solvent.The content of 2,6-difluorobenzenitrile was more than 99%and the yield was 90%.The synthesis process is simple with lowwer cost,higher yield and without catalyst.The process is suitable for industrial production.
作者
李瑞军
冯冰冰
温兴锋
孙建仁
Li Ruijun;Feng Bingbing;Wen Xingfeng;Sun Jianren(Zhengzhou University,College of Chemistry and Molecular Engineering,He’nan,450000;Zhejiang Huaji Biotechnology Co.Ltd.,Zhejiang,325024)
出处
《当代化工研究》
2019年第14期109-111,共3页
Modern Chemical Research
关键词
氟代反应
氟化钾
2
6-二氟苯腈
fluorination reaction
potassium fluoride
2
6-difluorobenzenitrile
