浅谈抑郁症脾虚病机与线粒体能量代谢障碍的相关性

Relationship between pathogenesis of spleen deficiency in depression and mitochondrial energy metabolism disorder

抑郁症是以情绪低落、思维迟缓、意志活动减退为主要特征的综合征。抑郁症脾虚是中医临床的常见证候,是抑郁症的重要病机,线粒体能量代谢障碍参与了抑郁症的病理生理过程,且脾虚病机的产生与线粒体能量代谢障碍存在密切的相关性,中医健脾益气药对抑郁症及线粒体损伤的改善作用明显。

Depression is a syndrome characterized by low spirit,mental retardation and decreased volitional activity.As a common TCM clinical pattern related to depression,spleen deficiency is an important pathogenesis of depression.Mitochondrial energy metabolism disorder often exists in the pathophysiological process of depression.The pathogenesis of spleen deficiency is closely related to mitochondrial energy metabolism disorder.Spleen-fortifying qi-boosting medicinals have obvious effects on depression and mitochondrial damage.