生血宝合剂联合铁剂治疗上消化道出血伴贫血的疗效观察

Therapeutic Effect of Shengxuebao Mixture Combined with Iron on Upper Gastrointestinal Hemorrhage with Anemia

目的:探讨生血宝合剂治疗上消化道出血伴贫血的临床疗效。方法:回顾性分析2015年1月~2017年12月在广东省第二中医院脾胃科收治的上消化道出血伴贫血患者140例,并随机分为对照组和治疗组各70例,对照组给予质子泵抑制剂和止血药物进行常规抑酸止血及口服铁剂治疗,治疗组则在此基础上给予生血宝合剂治疗,治疗4周后测定红细胞(RBC)、血红蛋白(HGB),观察两组临床疗效。结果:治疗组RBC、HGB水平改善程度显著优于对照组(P<0.05);治疗组痊愈率、总有效率为44.29%、94.29%,显著高于对照组的21.43%、78.57%(P<0.05);治疗组不良反应发生率为5.71%,显著低于对照组的17.14%(P<0.05)。结论:质子泵抑制剂和止血药治疗基础上,合用生血宝合剂治疗上消化道出血伴贫血效果好,安全性高。

Objective:To investigate the clinical effect of Shengxuebao Mixture on upper gastrointestinal hemorrhage with anemia. Methods:140 patients with upper digestive tract hemorrhage accompanied by anemia were retrospectively analyzed from January 2015 to December 2017 in Department of Spleen and Stomach of Guangdong Second Traditional Chinese Medicine Hospital, and randomly divided into control group(70 cases) and treatment group(70 cases). The control group was given proton pump inhibitors and hemostatic drugs for routine acid suppression and hemostasis and oral iron treatment, while treatment group combined with Shengxuebao Mixture, detected the red blood cell(RBC) and hemoglobin(HGB) after4 weeks of treatment and observed the efficacy of the two groups. Results:The improvement of RBC and HGB in treatment group were significantly better than control group(P<0.05);the cured rate and overall response rate in treatment group were 44.29% and 94.29%, which were significantly higher than 21.43% and 78.57% in control group(P<0.05);the incidence of adverse reaction in treatment group was 5.71%, which was significantly lower than 17.14% that in control group(P<0.05). Conclusion:Shengxuebao Mixture on the basis of proton pump inhibitors and hemostatic drugs is effective and safe in treating upper gastrointestinal hemorrhage with anemia.