摘要
目的探讨在冻融周期中移植优质囊胚数与临床结局的关系。方法回顾性分析2017年1月-12月在洛阳市妇女儿童医疗保健中心行冻融囊胚移植,且患者年龄≤38岁的395个周期,按移植优质囊胚数分为单优质囊胚组(A组37周期)、双非优质囊胚组(B组76周期)、双囊胚其中一个为优质组(C组85周期)、双优质囊胚组(D组197周期)。比较各组间的临床妊娠率、着床率、多胎率和流产率。结果 A组临床妊娠率显著低于D组(P<0.05);B组着床率显著低于D组(P<0.05);A组多胎率显著低于B、C、D组(P<0.05);流产率各组间无统计学差异(P>0.05)。结论单优质囊胚移植在显著降低多胎率的同时,能够获得满意的着床率,建议≤38岁的患者首次移植选择单优质囊胚移植。双囊胚移植多胎率过高,建议适当减少。
Objective To investigate the relationship between the number of high-quality blastocysts and clinical outcomes in frozen-thawed cycles.Methods A retrospective analysis was performed in 395 frozen-thawed blastocyst transfer cycles in our center from January to December 2017,and the age of the patients was no more than 38 years old. According to the number of high-quality blastocysts, the patients were divided into single high-quality blastocyst group(group A,37 cycles), double poor-quality blastocysts group(group B,76 cycles), one of the double blastocysts is high-quality group(group C,85 cycles) and double high-quality blastocysts group(group D,197 cycles). The clinical pregnancy rate, implantation rate, multiple pregnancy rate and abortion rate were compared among the groups.Results The clinical pregnancy rate of group A was significantly lower than that of group D(P<0.05), the implantation rate of group B was significantly lower than that of group D(P<0.05), the multiple pregnancy rate of group A was significantly lower than that of group B, C and D(P<0.05), and the abortion rate was not significantly different among groups(P>0.05).Conclusion Single high-quality blastocyst transplantation can achieve satisfactory implantation rate while significantly reducing the multiple pregnancy rate. It is suggested that the single high-quality blastocyst transplantation should be selected for the first transplant in patients under the age of 38. Double blastocyst transplantation rate of multiple births is too high, suggesting appropriate reduction.
作者
李静
白静
方东
郝白露
吴喆
LI Jing;BAI Jing;FANG Dong;HAO Bai-lu;WU Zhe(Reproductive Medical Center,Luoyang Women and Children Health Care Center,Luoyang,Henan 471000,China)
出处
《医药论坛杂志》
2019年第10期96-98,共3页
Journal of Medical Forum
关键词
冻融周期
囊胚移植
妊娠率
着床率
多胎率
Frozen-thawed cycles
Blastocyst transfer
Pregnancy rate
Implantation rate
Multiple pregnancy rate