D2-40和Prox1在弥漫性躯体性血管角化瘤及行性血管瘤中的表达差异

Difference in expression of lymphatic markers D2-40 and Prox1 between angiokeratoma corporis diffusum and angioma serpiginosum

目的探讨淋巴管标记在弥漫性躯体性血管角化瘤(ACD)及匐行性血管瘤(AS)鉴别诊断中的意义.方法回顾性分析2006-2017年西京皮肤医院确诊的9例ACD及6例AS患者的临床及组织病理学特点.对所有病例皮损均行CD31、D2-40及Prox1染色.结果9例ACD患者的异常脉管CD31呈弱阳性或阴性;ACD皮损异常管腔内皮细胞4例D2-40局灶阳性,5例D2-40阴性,9例Prox1阳性.6例AS患者增生的小血管内皮CD31阳性,而D2-40和Prox1均阴性.结论少数ACD及AS患者的临床特征有相似性,淋巴管标记在二者的鉴别诊断中具有明确的意义.

Objective To investigate the significance of lymphatic markers in the differential diagnosis of angiokeratoma corporis diffusum(ACD)and angioma serpiginosum(AS).Methods Totally,9 patients with ACD and 6 with AS were enrolled from Department of Dermatology,Xijing Hospital between 2006 and 2017,and their clinical and histopathological features were retrospectively analyzed.Skin sections from all the patients were stained for CD31,D2-40 and Prox1.Results In the 9 patients with ACD,abnormal vessels were weakly positive or negative for CD31,and positive for Prox1.Endothelial cells in abnormal vessels were locally positive for D2-40 in 4 patients with ACD,but negative for D2-40 in the other 5 patients.In the 6 patients with AS,the endothelia of hyperplastic small vessels were positive for CD31,but negative for D2-40 and Prox1.Conclusion The clinical features of a few patients with ACD are similar to those of patients with AS,and lymphatic markers have definite significance in the differential diagnosis of the two diseases.