植物源细菌群体感应抑制剂的研究进展

Research Progress on Bacteria Quorum Sensing Inhibitors of Plant-derived

细菌耐药性的出现已经成为全球公共卫生关注的问题之一,而传统处理耐药性的方法正逐渐失效,寻找新的作用靶点来开发新型抗菌药物至关重要。研究表明,靶向微生物群体感应(Quorum sensing,QS)是一种较好的替代传统抗生素的方法。从自然界中寻找群体感应系统抑制剂(Quorum sensing inhibitor,QSI),尤其是植物源QSI,被认为是解决微生物致病性和食品腐败的有效方法。本文在现有的理论和研究基础上,对植物源细菌群体感应抑制剂的研究现状进行综述,展望了群体感应抑制剂的研发前景,以期为细菌群体感应在微生物耐药性和开发新型防腐剂中的应用提供参考。

The emergence of bacterial resistance has become one of the concerns of global public health,and the traditional methods of dealing with drug resistance are gradually becoming invalid. It is essential to find new targets to develop new antimicrobial drugs. Studies have shown that targeting microbial quorum sensing(QS)seems to be a better alternative method to traditional antibiotics. The search for quorum sensing inhibitor(QSI)from nature,especially the plant-derived QSI,is considered to be an effective method to solve microbial pathogenicity and food spoilage. Based on the existing theories and research,this paper reviews the research status and functions of plant-derived bacterial quorum sensing inhibitors,and look forward to prospect the development of the quorum sensing inhibitors,so as to provide reference for the application of the bacteria quorum sensing inhibitors in microbial resistance and the development of new preservatives.