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他克莫司联合甲氨蝶呤治疗难治性类风湿关节炎临床效果观察 被引量:3

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摘要 目的:探析应用他克莫司联合甲氨蝶呤治疗难治性类风湿关节炎(RRA)的临床效果。方法:于2016年8月—2018年7月在我院选取62例RRA患者,以患者入院时间先后为依据将其分为平均的两组,即研究组(31例)与参照组(31例)。研究组采用他克莫司联合甲氨蝶呤进行治疗,参照组采用甲氨蝶呤与环磷酰胺进行治疗,对比两组用药方案的疗效。结果:治疗4个月后,研究组患者的VAS评分与DAS28评分均低于参照组;研究组患者治疗后的C-反应蛋白(CRP)、红细胞沉降率(ESR)、肿瘤坏死因子α(TNF-α)水平均低于参照组,差异有统计学意义(P<0.05)。结论:应用他克莫司和甲氨蝶呤对RRA进行联合治疗可有效提升治疗效果,减轻患者关节处的炎症反应,减轻患者疼痛感,有效缓解病情。
出处 《医学理论与实践》 2019年第21期3483-3484,共2页 The Journal of Medical Theory and Practice
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