耳后注射甲泼尼龙琥珀酸钠治疗突发性耳聋临床疗效的Meta分析

Meta-analysis of Clinical Efficacy of Methylprednisolone Sodium Succinate for Sudden Deafness by Retroauricular Injection

【目的】评价耳后注射甲泼尼龙琥珀酸钠治疗突发性耳聋的疗效.【方法】电子检索Pubmed、Medline、CNKI、CBM、维普、万方数据库,收集符合纳入标准的文献并提取数据,利用RevMan 5.3进行Meta分析.【结果】纳入14篇文献,Meta分析结果显示在常规治疗的基础上,耳后注射组疗效优于全身使用激素组,其RR(95%CI)为1.29(1.19,1.40);耳后注射组疗效优于除全身应用激素外的常规治疗,其RR(95%CI)为1.34(1.10,1.64);全身使用糖皮质激素治疗突发性聋的基础上再耳后注射甲泼尼龙琥珀酸钠,疗效高于常规治疗组,其RR(95%CI)为1.13(1.02,1.26).【结论】耳后注射甲泼尼龙琥珀酸钠治疗突发性耳聋疗效显著,在临床实践中值得推广.

【Objective】To evaluate the efficacy of retroauricular injection of methylprednisolone sodium succinate in the treatment of sudden deafness.【Methods】Pubm ed,Medline,CNKI,CBM,Weipu and Wanfang databases were retrieved electronically.Literatures that met the inclusion criteria were collected and data were extracted.RevMan 5.3 was used for meta-analysis.【Resuhs】14 literatures were included.Meta analysis showed that on the basis of routine treatment,the curative effect of retroauricular injection group was better than that of systemic hormone group,with RR(95%Cl)of 1.29(1.19,1.40);the curative effect of retroauricular injection group was better than that of routine treatment except systemic hormone,with RR(95%CI)of 1.34(1.10,1.64);and the effect of systemic glucocorticoid therapy was better than that of systemic hormone therapy for sudden deafness.After injection of methylprednisolone sodium succinate,the curative effect was higher than that of the conventional treatment group,its RR(95%CI)was 1.13(1.02,1.26).【Conclusion】Retroauricular injection of methylprednisolone sodium succinate is effective in the treatment of sudden deafness,which is worthy of promotion in clinical practice.