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子宫内膜癌组织miR-135b、HOXA10表达变化及其临床意义 被引量:1

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摘要 目的探讨子宫内膜癌组织微小RNA-135b(miR-135b)、同源盒基因家族A10(HOXA10)表达变化及其与患者临床病理特征的关系。方法选择子宫内膜癌患者73例,取手术切除的子宫内膜癌组织及其配对的癌旁正常组织,采用real-time PCR法检测miR-135b、HOXA10表达,观察子宫内膜癌组织miR-135b、HOXA10表达变化。分析子宫内膜癌组织miR-135b表达与HOXA10表达的关系及其与患者临床病理特征的关系。结果与癌旁正常组织比较,子宫内膜癌组织miR-135b相对表达量明显升高,HOXA10相对表达量明显降低(P均<0.01)。Pearson相关分析显示,子宫内膜癌组织miR-135b相对表达量与HOXA10相对表达量呈负相关关系(r=-0.496,P<0.01)。子宫内膜癌组织miR-135b、HOXA10相对表达量均与肿瘤浸润深度、FIGO分期、淋巴结转移有关(P均<0.05),而与患者年龄、绝经状态、病理类型、病理分级无关(P均>0.05)。结论子宫内膜癌组织miR-135b高表达、HOXA10低表达,二者表达变化与肿瘤恶性进展有关;下调HOXA10表达可能是miR-135b参与子宫内膜癌形成和恶性进展的机制之一。
机构地区 本溪市中心医院
出处 《山东医药》 CAS 2019年第31期55-58,共4页 Shandong Medical Journal
基金 辽宁省科学技术计划项目(2016020231)
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