孟鲁司特钠治疗小儿支气管哮喘合并变应性鼻炎的效果

Effect of Montelukast Sodium in the treatment of children with bronchial asthma complicated with allergic rhinitis

目的研究孟鲁司特钠治疗小儿支气管哮喘合并变应性鼻炎的效果。方法选取2017年6月~2018年8月海阳市妇幼保健院儿科收治的100例支气管哮喘合并变应性鼻炎患儿作为研究对象,并采用电脑随机法将其分为观察组和对照组,每组各50例。观察组患儿采用孟鲁司特钠治疗,对照组患儿采用氯雷他定治疗。比较两组患儿的治疗效果及治疗前后气道反应指标[最大呼气量(FEV)、呼气流量峰值(PEF)]、各项症状(哮喘、变应性鼻炎、感冒)评分。结果两组患儿治疗前的FEV、PEF比较,差异无统计学意义(P>0.05);两组患儿治疗后的FEV、PEF均高于治疗前,差异有统计学意义(P<0.05);观察组患儿治疗后的FEV[(2.91±0.59)L]、PEF[(6.95±1.21)L/s]均高于对照组[(2.21±0.21)L、(5.22±1.31)L/s],差异有统计学意义(P<0.05)。两组患儿治疗前的各项症状评分比较,差异无统计学意义(P>0.05);两组患儿治疗后的哮喘、变应性鼻炎、感冒症状评分均低于治疗前,差异有统计学意义(P<0.05);观察组患儿治疗后的哮喘[(2.02±0.32)分]、变应性鼻炎[(2.35±0.32)分]、感冒症状评分[(1.01±0.12)分]均低于对照组[(3.66±1.15)、(3.91±0.21)、(1.69±0.32)分],差异有统计学意义(P<0.05)。观察组患儿的治疗总有效率为98.00%,高于对照组的74.00%,差异有统计学意义(P<0.05)。结论孟鲁司特钠治疗小儿支气管哮喘合并变应性鼻炎的效果显著,且安全性高,值得研究。

Objective To study the effect of Montelukast Sodium in the treatment of children with bronchial asthma complicated with allergic rhinitis.Methods One hundred children with bronchial asthma complicated with allergic rhinitis in the Department of Pediatrics of Haiyang Maternal and Child Health Hospital from June 2017 to August 2018 were enrolled in the study.They were divided into observation group and control group according to the computer randomization method,50 cases in each group.The children in the observation group were treated with Montelukast Saodium,and the children in the control group were treated with Loratadine.The therapeutic effect and the airway response indicators(maximum expiratory volume[FEV],peak expiratory flow[PEF]),and various symptom(asthma,allergic rhinitis,cold)scores were compared in the two groups of children before and after treatment.Results There were no significant differences in the FEV and PEF between the two groups before treatment(P>0.05).The FEV and PEF of the two groups after treatment were higher than those before treatment,and the differences were statistically significant(P<0.05).The FEV([2.91±0.59]L)and PEF([6.95±1.21]L/s)in the observation group after treatment were higher than those in the control group([2.21±0.21]L,[5.22±1.31]L/s),and the differences were statistically significant(P<0.05).There were no significant differences in the scores of the symptoms between the two groups before treatment(P>0.05).The symptom scores of asthma,allergic rhinitis and cold of the two groups after treatment were lower than those before treatment,and the differences were statistically significant(P<0.05).The symptom scores of asthma([2.02±0.32]points),allergic rhinitis([2.35±0.32]points)and cold([1.01±0.12]points)in the observation group after treatment were lower than those in the control group([3.66±1.15],[3.91±0.21],[1.69±0.32]points),and the differences were statistically significant(P<0.05).The total effective rate of treatment in the observation group was 98.00%,which was higher than that in the control group(74.00%),and the difference was statistically significant(P<0.05).Conclusion The effect of Montelukast Sodium in the treatment of bronchial asthma complicated with allergic rhinitis in children is significant and safe,which is worthy of study.