蜡样芽孢杆菌胶囊辅助抗生素治疗婴幼儿支气管肺炎继发腹泻的临床效果

Clinical effect of Bacillus cereus capsule assisted with antibiotics in the treatment of diarrhea secondary to infantile bronchopneumonia

目的探讨蜡样芽孢杆菌胶囊辅助抗生素治疗婴幼儿支气管肺炎继发腹泻的临床效果。方法利用密集抽样法选取2016年12月~2018年12月本院收治的48例婴幼儿支气管肺炎继发腹泻患儿作为研究对象,采用摸球法将其分为研究组和对照组,每组各24例。研究组患儿给予蜡样芽孢杆菌胶囊辅助抗生素治疗,对照组患儿给予补液对症处理及抗生素治疗。比较两组患儿的症状体征(腹泻、腹痛、大便性状)改善时间、大便镜检及细菌培养恢复正常时间、治疗总有效率及不良反应发生情况。结果研究组患儿的腹泻、腹痛、大便性状改善时间短于对照组,大便镜检及细菌培养恢复正常时间短于对照组,差异均有统计学意义(P<0.05)。研究组患儿的治疗总有效率(95.83%)高于对照组(66.67%),差异有统计学意义(P<0.05)。治疗期间,两组患儿的不良反应发生率比较,差异无统计学意义(P>0.05)。结论婴幼儿支气管肺炎继发腹泻患儿抗生素治疗期间辅以蜡样芽孢杆菌胶囊可调节肠道菌群,增强疗效,促使症状体征尽快恢复,且不良反应少,值得临床推广。

Objective To investigate the clinical effect of Bacillus cereus capsule assisted with antibiotics in the treatment of diarrhea secondary to infantile bronchopneumonia.Methods Forty-eight infants and young children with secondary diarrhea caused by bronchopneumonia admitted to our hospital from December 2016 to December 2018 were selected as research objects by intensive sampling method,and were divided into study group and control group by ball touching method,with 24 cases in each group.The infants and young children in the study group were treated with Bacillus cereus capsules and antibiotics,while the infants and young children in the control group were given symptomatic treatment of fluid infusion and antibiotic treatment.The improvement time of symptoms and signs(diarrhea,abdominal pain,stool characteristics),stool microscopy and bacterial culture recovery time,total effective rate of treatment and adverse reactions were compared between the two groups.Results The improvement time of diarrhea,abdominal pain and stool characteristics in the study group were shorter than that in the control group,and the recovery time of stool microscopic examination and bacterial culture was shorter than that in the control group,the differences were statistically significant(P<0.05).The total effective rate(95.83%)in the study group was higher than that in the control group(66.67%),and the difference was statistically significant(P<0.05).During the treatment,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Bacillus cereus capsule can regulate intestinal flora,enhance curative effect and promote recovery of symptoms and signs as soon as possible during antibiotic treatment of infantile bronchopneumonia secondary diarrhea with few adverse reactions,which is worthy of clinical promotion.