羟基酪醇的药理作用研究进展

Progresses in Pharmacological Effects of Hydroxytyrosol

长期摄入橄榄油有助于降低心血管疾病、神经系统疾病、癌症等的发生风险。橄榄油中的次要化合物,特别是明星分子羟基酪醇,在橄榄油诸多健康效应中发挥了重要作用。作为一种多酚类化合物,羟基酪醇既可以直接清除氧化性物质,又可以通过调节以核转录因子E2相关因子2(nuclear factor erythroid-2 related factor 2,Nrf2)为核心的二相酶抗氧化系统间接抑制氧化应激,在预防/治疗多种氧化损伤相关疾病中具有巨大潜力。笔者重点介绍羟基酪醇在防治神经系统疾病、心血管疾病、代谢综合征、炎症、肿瘤等疾病方面取得的最新进展。

Long-term consumption of olive oil helps reduce the risks of developing a series of diseases including cardiovascular disease,nervous system disease,cancer,etc.The minor compounds of olive oil,especially the star molecule——hydroxytyrosol,play an important role in these beneficial effects on human health.As a polyphenolic compound,hydroxytyrosol not only act as antioxidant and scavenge oxidizing substances directly,but also inhibit oxidative stress by regulating the Nrf2 antioxidant system.Thus,hydroxytyrosol has great potential in the prevention and treatment of oxidative damage related diseases.This review focuses mainly on recent progresses in pharmacological effects of hydroxytyrosol on nervous system disease,angiocardiopathy,metabolic syndrome,inflammation and cancer.