植物多糖受体研究进展

Research Progress of Receptors of Plant Polysaccharides

植物多糖类药物作用的受体以及其介导的信号通路成为多糖活性研究的热点,多糖作为免疫调节剂通过细胞表面受体介导的免疫调节作用得到了广泛关注。多糖受体主要包括C型凝集素受体家族、甘露糖受体家族(MR)、Toll样受体家族(TLR)、补体受体3(CR3)、清道夫受体等,这些受体在多糖与细胞识别和产生活性的过程中起到重要作用,从而使多糖可以增强细胞免疫功能,调节细胞因子分泌,起到免疫调节和抗肿瘤作用。笔者对植物多糖受体的类型、分子生物学功能以及信号传导通路进行综述,有助于阐明植物多糖药理活性的作用机制,可为多糖类药物综合开发提供理论参考。

Receptors of plant polysaccharides and their signaling pathways have become a hotspot of polysaccharide activity research.As immunomodulators,polysaccharides have attracted much attention due to their immunomodulatory effects mediated by cell surface receptors.Polysaccharide receptors mainly include C-type lectin receptor family,mannose receptor family(MR),Toll-like receptor family(TLR),complement receptor 3(CR3),scavenger receptor and so on,and these receptors play an important role in the recognition between polysaccharides and cells,which is closely related to polysaccharides activities,such as enhancing cellular immune function,regulating the secretion of cytokines,having immunomodulatory and antineoplastic effects.In this paper,polysaccharide receptors types,biological functions and signal transduction pathways are reviewed,it will be helpful to elucidate the pharmacological activity mechanism of plant polysaccharides and provide theoretical reference for the comprehensive development of polysaccharide drugs.